Viraj B. Gandhi
Abbott Fund(US)
Publications by Year
Research Areas
PARP inhibition in cancer therapy, PI3K/AKT/mTOR signaling in cancer, Integrated Circuits and Semiconductor Failure Analysis, DNA Repair Mechanisms, Quinazolinone synthesis and applications
Most-Cited Works
- → Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer(2008)266 cited
- → Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer(2008)74 cited
- → Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor(2010)70 cited
- → Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension(2007)62 cited
- → Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt(2007)62 cited
- → Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers(2006)49 cited
- → Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent(2008)45 cited
- → Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity(2006)36 cited
- → Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer(2009)35 cited
- → Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer(2012)29 cited