Lauren Dare
Royal Hobart Hospital(AU)
Publications by Year
Research Areas
Cell death mechanisms and regulation, interferon and immune responses, Inflammasome and immune disorders, Bone health and osteoporosis research, Immune Response and Inflammation
Most-Cited Works
- → Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases(2017)466 cited
- → Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice(2014)369 cited
- → DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors(2016)269 cited
- → Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity(2012)254 cited
- → Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate(2001)153 cited
- → Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase(2015)146 cited
- → A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys(2006)136 cited
- → Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis(2013)135 cited
- → MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses(2015)83 cited
- → Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy(2001)16 cited