Andrew Phimister
Novartis (United States)(US)
Publications by Year
Research Areas
Carcinogens and Genotoxicity Assessment, Sulfur Compounds in Biology, Toxic Organic Pollutants Impact, Ion channel regulation and function, Drug Transport and Resistance Mechanisms
Most-Cited Works
- → Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials(2013)408 cited
- → Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)(2017)225 cited
- → Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats(2008)163 cited
- → Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis(2020)97 cited
- → Conformation-dependent Stability of Junctophilin 1 (JP1) and Ryanodine Receptor Type 1 (RyR1) Channel Complex Is Mediated by Their Hyper-reactive Thiols(2007)63 cited
- → Glutathione Depletion Is a Major Determinant of Inhaled Naphthalene Respiratory Toxicity and Naphthalene Metabolism in Mice(2004)60 cited
- → In Situ Naphthalene Bioactivation and Nasal Airflow Cause Region-Specific Injury Patterns in the Nasal Mucosa of Rats Exposed to Naphthalene by Inhalation(2005)31 cited
- → Consequences of Abrupt Glutathione Depletion in Murine Clara Cells: Ultrastructural and Biochemical Investigations into the Role of Glutathione Loss in Naphthalene Cytotoxicity(2005)24 cited
- → Prevention of naphthalene‐induced pulmonary toxicity by glutathione prodrugs: Roles for glutathione depletion in adduct formation and cell injury(2005)18 cited
- → Dissociation constants of carboxylic acids by 13C-NMR in(1999)18 cited