Christian Wiesmann
Novartis (China)(CN)
Publications by Year
Research Areas
Monoclonal and Polyclonal Antibodies Research, Angiogenesis and VEGF in Cancer, Glycosylation and Glycoproteins Research, Complement system in diseases, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling(2004)1,815 cited
- → The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer(2008)741 cited
- → Allosteric inhibition of protein tyrosine phosphatase 1B(2004)523 cited
- → The discovery of first-in-class drugs: origins and evolution(2014)496 cited
- → Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor(1997)485 cited
- → Cryo-EM in drug discovery: achievements, limitations and prospects(2018)463 cited
- → Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson(1999)446 cited
- → Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor(1999)409 cited
- → Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site(2009)363 cited
- → High-throughput Generation of Synthetic Antibodies from Highly Functional Minimalist Phage-displayed Libraries(2007)361 cited