Eric P. Arnold

Publications by Year

Research Areas

Nicotinic Acetylcholine Receptors Study, Receptor Mechanisms and Signaling, Chemical synthesis and alkaloids, Cytokine Signaling Pathways and Interactions, Crystallization and Solubility Studies

Most-Cited Works

• → Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation(2005)930 cited
• → Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)(2018)170 cited
• → Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases(2018)163 cited
• → Total Synthesis of (±)-Cytisine(2000)89 cited
• → 3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation(2005)73 cited
• → Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases(2020)73 cited
• → In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine(2005)67 cited
• → Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1(2014)37 cited
• → Ligand–Protein Interactions of Selective Casein Kinase 1δ Inhibitors(2013)32 cited
• → Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor(2017)32 cited