Linda E. Keown
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Marine Sponges and Natural Products, Asymmetric Synthesis and Catalysis, Microbial Natural Products and Biosynthesis, Neuropeptides and Animal Physiology
Most-Cited Works
- → Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets(1996)211 cited
- → Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.(2001)116 cited
- → Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A)(1997)102 cited
- → Total Synthesis of Rhizoxin D, a Potent Antimitotic Agent from the Fungus Rhizopus chinensis(2002)86 cited
- → N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists(1996)66 cited
- → The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment(2005)36 cited
- → Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity(2009)26 cited
- → 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution(1997)18 cited
- → Morpholine-based substance P antagonists: assessment of the 3-point binding model(1994)8 cited