Maria M. Toteva
Gilead Sciences (United States)(US)
Publications by Year
Research Areas
Chemical Reaction Mechanisms, Chemical Reactions and Mechanisms, DNA and Nucleic Acid Chemistry, Synthesis of Indole Derivatives, Analytical Chemistry and Chromatography
Most-Cited Works
- → Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development(2014)291 cited
- → The generation and reactions of quinone methides(2011)177 cited
- → Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction(2012)167 cited
- → Formation and Stability of Carbocations and Carbanions in Water and Intrinsic Barriers to Their Reactions(2001)152 cited
- → A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents(2012)136 cited
- → Mechanism for Nucleophilic Substitution and Elimination Reactions at Tertiary Carbon in Largely Aqueous Solutions: Lifetime of a Simple Tertiary Carbocation(1996)81 cited
- → Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV(2021)81 cited
- → Structure−Reactivity Relationships and Intrinsic Reaction Barriers for Nucleophile Additions to a Quinone Methide: A Strongly Resonance-Stabilized Carbocation(2000)65 cited
- → What Is the Stabilizing Interaction with Nucleophilic Solvents in the Transition State for Solvolysis of Tertiary Derivatives: Nucleophilic Solvent Participation or Nucleophilic Solvation?(2001)60 cited
- → Substituent Effects on Carbocation Stability: The pKR for p-Quinone Methide(2003)53 cited