Heath A. McDonald

Publications by Year

Research Areas

Ion Channels and Receptors, Pain Mechanisms and Treatments, Ion channel regulation and function, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography

Most-Cited Works

• → TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists(2006)311 cited
• → Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation(2011)269 cited
• → Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties(2005)163 cited
• → A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid(2005)110 cited
• → TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics(2002)110 cited
• → TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development(2018)87 cited
• → Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature(2012)83 cited
• → Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management(2008)80 cited
• → Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis(2019)67 cited
• → TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells(2006)65 cited