Karl P. Hodel
Publications by Year
Research Areas
Cancer Genomics and Diagnostics, Genetic factors in colorectal cancer, Epigenetics and DNA Methylation, RNA modifications and cancer, DNA Repair Mechanisms
Most-Cited Works
- → Comprehensive Analysis of Hypermutation in Human Cancer(2017)786 cited
- → Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers(2015)378 cited
- → DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells(2020)84 cited
- → POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status(2020)69 cited
- → Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair(2018)39 cited
- → Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade(2020)25 cited
- → Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development(2022)8 cited
- → Author response: Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair(2018)
- → Abstract 2500: Technical feasibility of CRISPR-based functional profiling for solid tumor precision medicine(2024)
- → Abstract 3352: A CRISPR-enabled function genomics profiling platform in acute leukemia: Updates from a pilot study of Function (Fx) Heme utilizing fresh patient samples(2024)