James P. Villa
GlaxoSmithKline (United States)(US)
Publications by Year
Research Areas
Protease and Inhibitor Mechanisms, Cell Adhesion Molecules Research, Peptidase Inhibition and Analysis, Biochemical and Structural Characterization, Atmospheric chemistry and aerosols
Most-Cited Works
- → Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode(2009)63 cited
- → Chemical Mechanism of a Cysteine Protease, Cathepsin C, As Revealed by Integration of both Steady-State and Pre-Steady-State Solvent Kinetic Isotope Effects(2008)41 cited
- → Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity(2003)39 cited
- → Meprin proteolytic complexes at the cell surface and in extracellular spaces(2003)36 cited
- → Probing the Active Sites and Mechanisms of Rat Metalloproteases Meprin A and B(2002)33 cited
- → Kinetic Mechanism and Rate-Limiting Steps of Focal Adhesion Kinase-1(2010)13 cited
- → Zinc Ligands in an Astacin Family Metalloprotease Meprin A(2002)9 cited
- → Abstract 5418: Rapid LDH5 inhibition reverses malignant metabolic phenotype and impairs survival of hepatocellular carcinoma cells .(2013)2 cited
- Computational studies on enzymatic phosphate hydrolysis(2003)
- → The Effects Of Acid Rain(2010)