Philip D. Edwards

Publications by Year

Research Areas

Chemical Synthesis and Analysis, Computational Drug Discovery Methods, Cell Adhesion Molecules Research, Peptidase Inhibition and Analysis, Protease and Inhibitor Mechanisms

Most-Cited Works

• → Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency(2007)211 cited
• → Synthetic Inhibitors of Elastase(1994)210 cited
• → Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation(2007)148 cited
• → Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines(2002)145 cited
• → Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole(1992)144 cited
• → Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase(2007)142 cited
• → An Integrated Approach to Fragment-Based Lead Generation:Philosophy, Strategy and Case Studies from AstraZenecas Drug Discovery Programmes(2007)127 cited
• → Conversion of Cystitis Glandularis to Adenocarcinoma(1972)110 cited
• → .alpha.-Amino carbanions via formamidines. Alkylation of pyrrolidines, piperidines, and related heterocycles(1984)109 cited
• → 2 Inhibitors of Human Leukocyte Elastase(1994)77 cited