Christopher F. Bigge
Pfizer (United States)(US)
Publications by Year
Research Areas
Neuroscience and Neuropharmacology Research, Chemical Synthesis and Analysis, Ion channel regulation and function, Synthesis and Biological Evaluation, Blood Coagulation and Thrombosis Mechanisms
Most-Cited Works
- → Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines(1999)95 cited
- → Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists(1992)64 cited
- → Ionotropic glutamate receptors(1999)60 cited
- → Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists(1992)59 cited
- → Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity(1995)58 cited
- → A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides(2006)56 cited
- → Palladium-catalyzed coupling reactions of uracil nucleosides and nucleotides(1980)56 cited
- → Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ(2011)52 cited
- → Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists(1993)51 cited
- → Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists(1989)45 cited