Paolo Mellini
Kyoto Prefectural University of Medicine(JP)
Publications by Year
Research Areas
Sirtuins and Resveratrol in Medicine, Autophagy in Disease and Therapy, PARP inhibition in cancer therapy, Epigenetics and DNA Methylation, Calcium signaling and nucleotide metabolism
Most-Cited Works
- → Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells(2012)98 cited
- → 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells(2015)78 cited
- → Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD+-binding site(2017)70 cited
- → SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action(2017)64 cited
- → Studying SIRT6 regulation using H3K56 based substrate and small molecules(2014)55 cited
- → Sirtuin modulators: an updated patent review (2012 – 2014)(2014)53 cited
- → The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells(2017)51 cited
- → Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines(2018)48 cited
- → Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives(2012)40 cited
- → Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells(2013)37 cited