Ken Itoh
Hirosaki University(JP)
Publications by Year
Research Areas
Genomics, phytochemicals, and oxidative stress, Glutathione Transferases and Polymorphisms, Air Quality and Health Impacts, Redox biology and oxidative stress, Free Radicals and Antioxidants
Most-Cited Works
- → An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements(1997)3,915 cited
- → Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain(1999)3,543 cited
- → Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants(2002)1,909 cited
- → Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages(2000)1,451 cited
- → Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression(2003)1,122 cited
- → Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice