Andrea Testa
Amicus Therapeutics (United Kingdom)(GB)Granta Design (United Kingdom)(GB)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis, Multiple Myeloma Research and Treatments, Medical Imaging Techniques and Applications
Most-Cited Works
- → Structural basis of PROTAC cooperative recognition for selective protein degradation(2017)1,136 cited
- → Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7(2018)326 cited
- → Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation(2017)236 cited
- → Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity(2021)228 cited
- → Structure‐Based Design of a Macrocyclic PROTAC(2019)226 cited
- → Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds(2017)217 cited
- → Targeted protein degradation via intramolecular bivalent glues(2024)161 cited
- → 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation(2018)145 cited
- → Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader(2019)142 cited
- → Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs(2019)139 cited