Jacob M. Loupe
HudsonAlpha Institute for Biotechnology(US)
Publications by Year
Research Areas
Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Genomics and Chromatin Dynamics, Single-cell and spatial transcriptomics, RNA Research and Splicing
Most-Cited Works
- → CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset(2019)541 cited
- → Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out(2020)90 cited
- → Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements(2023)81 cited
- → Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects(2020)74 cited
- → Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease(2019)44 cited
- → Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs(2021)35 cited
- → Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation(2011)26 cited
- → Multiomic profiling of transcription factor binding and function in human brain(2024)20 cited
- → Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options(2015)19 cited
- → Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation(2012)19 cited