Karin Kolmodin
Sprint Bioscience (Sweden)(SE)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Alzheimer's disease research and treatments, Protein Tyrosine Phosphatases, ATP Synthase and ATPases Research, Cholinesterase and Neurodegenerative Diseases
Most-Cited Works
- → Q: a molecular dynamics program for free energy calculations and empirical valence bond simulations in biomolecular systems(1998)325 cited
- → Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency(2007)211 cited
- → Mechanistic alternatives in phosphate monoester hydrolysis: What conclusions can be drawn from available experimental data?(1999)147 cited
- → State-of-the-art Tools for Computational Site of Metabolism Predictions: Comparative Analysis, Mechanistical Insights, and Future Applications(2007)140 cited
- → Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease(2012)136 cited
- → The catalytic mechanism of protein tyrosine phosphatases revisited(2001)106 cited
- → Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides(2012)99 cited
- → Design, Synthesis, Computational Prediction, and Biological Evaluation of Ester Soft Drugs as Inhibitors of Dihydrofolate Reductase fromPneumocystis carinii(2001)90 cited
- → Design of compound libraries for fragment screening(2009)79 cited
- → New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain(2012)65 cited