George S. Sheppard
AbbVie (United States)(US)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Multiple Myeloma Research and Treatments, CAR-T cell therapy research, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis
Most-Cited Works
- → Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)(2015)427 cited
- → Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer(2020)393 cited
- → Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR(1997)317 cited
- → Diastereoselective aldol reactions using .beta.-keto imide derived enolates. A versatile approach to the assemblage of polypropionate systems(1990)259 cited
- → Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity(2015)150 cited
- → Total Synthesis of the Polyether Antibiotic Lonomycin A (Emericid)(1995)145 cited