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William McCoull | doi.page

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William McCoull

The Francis Crick Institute(GB)AstraZeneca (Singapore)(SG)AstraZeneca (Poland)(PL)

Publications by Year

Research Areas

Cytokine Signaling Pathways and Interactions, Mathematical Biology Tumor Growth, Synthesis and Catalytic Reactions, Computational Drug Discovery Methods, Asymmetric Synthesis and Catalysis

Most-Cited Works

→ Recent Synthetic Applications of Chiral Aziridines(2000)578 cited
→ Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6(2018)136 cited
→ Concise Asymmetric Synthesis of α-Amino Acid Derivatives from N-Sulfinylimino Esters(1999)128 cited
→ Asymmetric Synthesis of Aziridine 2-Phosphonates from Enantiopure Sulfinimines (N-Sulfinyl Imines). Synthesis of α-Amino Phosphonates(2003)103 cited
→ Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy(2021)90 cited
→ Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors(2017)78 cited

→ Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen(1997)77 cited

→ Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen(2001)76 cited

→ Asymmetric synthesis of aziridine 2-phosphonates and azirinyl phosphonates from enantiopure sulfinimines(1999)71 cited

→ AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia(2020)67 cited