Aleksandr Kolesnikov
Publications by Year
Research Areas
Blood Coagulation and Thrombosis Mechanisms, Coagulation, Bradykinin, Polyphosphates, and Angioedema, Hemophilia Treatment and Research, Synthesis and biological activity, NF-κB Signaling Pathways
Most-Cited Works
- → Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity(2013)175 cited
- → Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa(2001)124 cited
- → Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma(2019)64 cited
- → Optimization of a screening lead for factor VIIa/TF(2001)45 cited
- → Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling(2018)39 cited
- → Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma(2019)36 cited
- → Potent 4-amino-5-azaindole factor VIIa inhibitors(2006)34 cited
- → Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model(2006)30 cited
- → Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors(2019)30 cited
- → Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability(2017)28 cited