A. Rosowsky
Harvard University(US)Dana-Farber Cancer Institute(US)
Publications by Year
Research Areas
Biochemical and Molecular Research, HIV/AIDS drug development and treatment, Synthesis of heterocyclic compounds, Metal complexes synthesis and properties, Folate and B Vitamins Research
Most-Cited Works
- → 2,4-Diaminothieno[2,3-d]pyrimidines as antifolates and antimalarials. 2. Synthesis of 2,4-diaminopyrido[4',3':4,5]thieno[2,3-d]pyrimidines and 2,4-diamino-8H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidines(1973)64 cited
- → Structure‐based approach to pharmacophore identification, in silico screening, and three‐dimensional quantitative structure–activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function(2008)42 cited
- → Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.(1994)27 cited
- → Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. 47. N-[4-[[(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl-L-glutamic acid, a novel a-ring analog of 2-desamino-5,8-dideazafolic acid(1992)19 cited
- → 1,2-Dithiol-3-thione and dithioester analogues: potential radioprotectors(1990)15 cited
- → Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogs of aminopterin and methotrexate(1991)11 cited
- → Assay for Mitolactol and Its Bifunctional Alkylating Metabolites in Plasma(1985)5 cited
- → ChemInform Abstract: 4‐Amino‐3‐(2,3,5‐tri‐O‐benzyl‐β‐D‐ribofuranosyl)‐5‐pyrazolecarbonitrile. Synthesis and Conversion into a Sugar‐Blocked 5,7‐Disubstituted Formycin Analog.(1988)
- → Inhibition of Dihydrofolate Reductase and Thymidylate Synthase by Methotrexate Polyglutamate Analogues Lacking "Internal" α-Carboxyl Groups(1986)