Kwok-Ho Chan
Age UK(GB)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Multiple Myeloma Research and Treatments, Peptidase Inhibition and Analysis, RNA and protein synthesis mechanisms
Most-Cited Works
- → Structural basis of PROTAC cooperative recognition for selective protein degradation(2017)1,136 cited
- → Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4(2015)1,016 cited
- → Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity(2021)228 cited
- → Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds(2017)217 cited
- → A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes(2014)146 cited
- → 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation(2018)145 cited
- → Understanding and Improving the Membrane Permeability of VH032-Based PROTACs(2020)130 cited
- → Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins(2021)105 cited
- → Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System(2020)66 cited
- → Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition(2018)50 cited