Jesus M. Ontoria
IRBM Science Park(IT)
Publications by Year
Research Areas
Hepatitis C virus research, Histone Deacetylase Inhibitors Research, HIV/AIDS drug development and treatment, PARP inhibition in cancer therapy, Peptidase Inhibition and Analysis
Most-Cited Works
- → Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors(2009)308 cited
- → 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors(2008)64 cited
- → Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy(2009)61 cited
- → Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(2009)55 cited
- → Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase(2006)45 cited
- → Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors(2009)45 cited
- → The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease(2004)44 cited
- → Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs(2016)40 cited
- → Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides(2018)32 cited
- → Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model(2009)31 cited