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Gerry McLachlan | doi.page

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Gerry McLachlan

Roslin Institute(GB)Frimley Park Hospital(GB)Frimley Health NHS Foundation Trust(GB)Cell and Gene Therapy Catapult(GB)University of Edinburgh(GB)

Publications by Year

Research Areas

Virus-based gene therapy research, Cystic Fibrosis Research Advances, Neonatal Respiratory Health Research, Viral gastroenteritis research and epidemiology, RNA Interference and Gene Delivery

Most-Cited Works

→ Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial(2015)420 cited
→ Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice(1993)399 cited
→ Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis(1997)323 cited
→ Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis(2016)143 cited
→ Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens(1995)135 cited
→ Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung(2011)103 cited

Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation.(1996)

→ Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes(2008)82 cited

Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP.(1996)

Evaluation in vitro and in vivo of cationic liposome-expression construct complexes for cystic fibrosis gene therapy.(1995)