Sophie Mukadam
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Computational Drug Discovery Methods, Drug Transport and Resistance Mechanisms, Statistical Methods in Clinical Trials, Biochemical and Molecular Research
Most-Cited Works
- → Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies(2012)110 cited
- → Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model(2016)99 cited
- → Drug–Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug–Drug Interaction Prediction(2012)94 cited
- → Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition(2012)66 cited
- → Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates(2014)47 cited
- → Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349(2012)46 cited
- → Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties(2013)41 cited
- → Potent Non-Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors from Genetic Engineering of Streptomyces hygroscopicus(2009)33 cited
- → In vitroandin vivocharacterization of CYP inhibition by 1‐aminobenzotriazole in rats(2015)25 cited
- → Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach(2012)24 cited