Karel M. J. Brands
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Asymmetric Synthesis and Catalysis, Synthetic Organic Chemistry Methods, Chemical synthesis and alkaloids, Marine Sponges and Natural Products
Most-Cited Works
- → Crystallization-Induced Diastereomer Transformations(2006)202 cited
- → Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation(2003)156 cited
- → Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)(2011)122 cited
- → Regioselective Synthesis of 1,3,5-Substituted Pyrazoles from Acetylenic Ketones and Hydrazines(2003)103 cited
- → The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder(2011)100 cited
- → Total Synthesis of (-)-Altemicidin: A Novel Exploitation of the Potier-Polonovski Rearrangement(1995)69 cited
- → Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction(2002)65 cited
- → Synthesis of the homochiral “tricyclic heart” of manzamine A(1991)63 cited
- → Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition(2006)53 cited
- → Synthesis of the “tricyclic heart” of manzamines(1989)39 cited