Clare I. Hobbs

Publications by Year

Research Areas

Protein Degradation and Inhibitors, Computational Drug Discovery Methods, RNA and protein synthesis mechanisms, Chemical Synthesis and Analysis, Ubiquitin and proteasome pathways

Most-Cited Works

• → 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain(2014)89 cited
• → Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library(2015)83 cited
• → GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain(2016)65 cited
• → Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor(2011)54 cited
• → Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase(2017)46 cited
• → Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors(2016)44 cited
• → The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits(2015)42 cited
• → Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design(2013)28 cited
• → Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates(2008)17 cited
• → Tipping points in open systems: bifurcation, noise-included and rate-dependent examples in the climate system(2013)6 cited