David J. Richard

Publications by Year

Research Areas

PI3K/AKT/mTOR signaling in cancer, Synthesis and biological activity, Protein Kinase Regulation and GTPase Signaling, Synthetic Organic Chemistry Methods, Synthesis and Biological Activity

Most-Cited Works

• → ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines(2009)98 cited
• → Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors(2009)97 cited
• → Cyclopeptide alkaloids: chemistry and biology(2004)81 cited
• → Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent(2010)63 cited
• → Total Synthesis of Isoroquefortine C(2001)59 cited
• → Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker(2013)54 cited
• → Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent(2009)53 cited
• → Direct determination of iron(II), iron(III) and total iron as UV-absorbing complexes by capillary electrophoresis(1996)49 cited
• → Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)(2015)48 cited
• → Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle(2004)44 cited