Beth Pietrak
Johnson & Johnson (United States)(US)Springhouse(US)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Protein Structure and Dynamics, Chemical Synthesis and Analysis, Cholinesterase and Neurodegenerative Diseases
Most-Cited Works
- → Reductive carboxylation supports redox homeostasis during anchorage-independent growth(2016)592 cited
- → Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)(2004)273 cited
- → Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction(2014)206 cited
- → Crystallographic structure of a small molecule SIRT1 activator-enzyme complex(2015)198 cited
- → New IDH1 mutant inhibitors for treatment of acute myeloid leukemia(2015)176 cited
- → A Tale of Two Subunits: How the Neomorphic R132H IDH1 Mutation Enhances Production of αHG(2011)109 cited
- → First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates(2008)105 cited
- → LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease(2006)94 cited
- → Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors(2004)93 cited
- → Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model(2006)91 cited