Sandra Lightle
Pfizer (United States)(US)Zoetis (United States)(US)
Publications by Year
Research Areas
Enzyme Structure and Function, Bacterial Genetics and Biotechnology, Biotin and Related Studies, Antibiotic Resistance in Bacteria, RNA and protein synthesis mechanisms
Most-Cited Works
- → Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches(2009)105 cited
- → The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme,(2006)87 cited
- → Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase(2008)85 cited
- → Comparative functional characterization of canine IgG subclasses(2013)78 cited
- → Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB‐78485 inhibitor(2008)57 cited
- → Structure of a small‐molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site(2008)50 cited
- → Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)(2007)43 cited
- → Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC(2012)32 cited
- → Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding(2010)30 cited
- → Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain(2009)20 cited