Derek Vrieze
Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Asymmetric Synthesis and Catalysis, Asymmetric Hydrogenation and Catalysis, Chemical Synthesis and Analysis, Receptor Mechanisms and Signaling, Synthetic Organic Chemistry Methods
Most-Cited Works
- → A Highly Enantioselective Allylic Amination Reaction Using a Commercially Available Chiral Rhodium Catalyst: Resolution of Racemic Allylic Carbonates(2009)73 cited
- → Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate(2014)67 cited
- → The Preparation of Two, Preclinical Amino-quinazolinediones as Antibacterial Agents(2007)31 cited
- → Identification of (R)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic Acid, a Highly Potent and Selective Nonsteroidal Mineralocorticoid Receptor Antagonist(2014)27 cited
- → Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists(2014)19 cited
- → Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production(2007)19 cited
- → Spiroazetidine–piperidine bromoindane as a key modular template to access a variety of compounds via C–C and C–N bond-forming reactions(2012)12 cited
- → The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein(2009)11 cited
- → Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone(2012)11 cited
- → Substituent effects on the amination of racemic allyl carbonates using commercially available chiral rhodium catalysts(2013)10 cited