Scott D. Cowen
AstraZeneca (United States)(US)
Publications by Year
Research Areas
Protease and Inhibitor Mechanisms, Epigenetics and DNA Methylation, RNA modifications and cancer, Cytokine Signaling Pathways and Interactions, interferon and immune responses
Most-Cited Works
- → Structural Basis of Substrate Methylation and Inhibition of SMYD2(2011)194 cited
- → Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design(2001)136 cited
- → An improved model for fragment-based lead generation at AstraZeneca(2016)77 cited
- → Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases(2012)45 cited
- → Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors(2016)36 cited
- → Syntheses of 5a‘-homo-Vinblastine and Congeners Designed to Establish Structural Determinants for Isolation of Atropisomers(2001)33 cited
- → N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B(2003)28 cited
- → Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-ε kinases(2014)16 cited
- → Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity(2008)8 cited
- → Synthetic studies on highly oxygenated quassinoids: Total synthesis of (±)-14β,15β-dihydroxyklaineanone(1996)6 cited