Masako Wakitani
Kyowa Kirin (Japan)(JP)
Publications by Year
Research Areas
Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, Viral Infectious Diseases and Gene Expression in Insects, Protein purification and stability, Galectins and Cancer Biology
Most-Cited Works
- → Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity(2004)568 cited
- → Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa(2004)335 cited
- → IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides(2005)239 cited
- → Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa(2006)206 cited
- → Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities(2008)186 cited
- → Enhanced binding affinity for FcγRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity(2007)177 cited
- → Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA(2004)174 cited
- → Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC(2007)153 cited
- → Comparison of cell lines for stable production of fucose‐negative antibodies with enhanced ADCC(2006)113 cited
- → Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant region(2005)64 cited