Martha L. Minich

Publications by Year

Research Areas

Inflammatory mediators and NSAID effects, Microbial Natural Products and Biosynthesis, Neuropeptides and Animal Physiology, Carbohydrate Chemistry and Synthesis, Sulfur-Based Synthesis Techniques

Most-Cited Works

• → Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus(2011)115 cited
• → Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle(2009)80 cited
• → Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2(2009)58 cited
• → 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog(2005)51 cited
• → Synthesis of compounds designed to inhibit bacterial cell wall transglycosylation(1990)44 cited
• → Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors(2006)39 cited
• → Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine(2003)38 cited
• → Beta subunit copurifies with GppNHp-activated adenylyl cyclase.(1990)36 cited
• → 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers(2005)35 cited
• → 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile(2006)31 cited