J. Michael Bradshaw
Publications by Year
Research Areas
Chronic Lymphocytic Leukemia Research, Protein Structure and Dynamics, Protein Kinase Regulation and GTPase Signaling, Monoclonal and Polyclonal Antibodies Research, Enzyme Structure and Function
Most-Cited Works
- → Prolonged and tunable residence time using reversible covalent kinase inhibitors(2015)426 cited
- → The Src, Syk, and Tec family kinases: Distinct types of molecular switches(2010)258 cited
- → An ultrasensitive Ca 2+ /calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling(2003)197 cited
- → Molecular Mechanism of the Syk Activation Switch(2008)160 cited
- → Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase 1 1Edited by P. E. Wright(1999)146 cited
- → Molecular recognition by SH2 domains(2002)121 cited
- → Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease(2021)113 cited
- → Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors(2017)95 cited
- → Calorimetric Investigation of Proton Linkage by Monitoring both the Enthalpy and Association Constant of Binding: Application to the Interaction of the Src SH2 Domain with a High-Affinity Tyrosyl Phosphopeptide(1998)84 cited
- → Probing the “Two-Pronged Plug Two-Holed Socket” Model for the Mechanism of Binding of the Src SH2 Domain to Phosphotyrosyl Peptides: A Thermodynamic Study(1998)79 cited