John Frazer
Becton Dickinson (United States)(US)Eurofins (United States)(US)
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Neurotransmitter Receptor Influence on Behavior, Mast cells and histamine, Neuropeptides and Animal Physiology, Pharmacology and Obesity Treatment
Most-Cited Works
- → Functional assays for screening GPCR targets(2005)223 cited
- → Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor(2018)57 cited
- → Kinetics of 5-HT2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration(2013)54 cited
- → Isoaccepting transfer ribonucleic acids in liver and brain of young and old BC3F1 mice(1972)46 cited
- → A new family of H3 receptor antagonists based on the natural product Conessine(2007)31 cited
- → APD791, 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a Novel 5-Hydroxytryptamine 2A Receptor Antagonist: Pharmacological Profile, Pharmacokinetics, Platelet Activity and Vascular Biology(2009)25 cited
- → Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2AInverse Agonists for the Treatment of Insomnia(2010)22 cited
- → Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)(2011)17 cited
- → Design and Evaluation of Novel Biphenyl Sulfonamide Derivatives with Potent Histamine H3 Receptor Inverse Agonist Activity(2009)16 cited
- → Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis(2010)12 cited