Jonathan D.J. Wrigley
AstraZeneca (United Kingdom)(GB)
Publications by Year
Research Areas
Alzheimer's disease research and treatments, Computational Drug Discovery Methods, Cholinesterase and Neurodegenerative Diseases, Drug Transport and Resistance Mechanisms, Neuroscience and Neuropharmacology Research
Most-Cited Works
- → Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site(2004)178 cited
- → BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B(2018)97 cited
- → Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily(2017)85 cited
- → Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel γ-Secretase Inhibitor(2001)85 cited
- → Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity(2002)82 cited
- → In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand(2003)80 cited
- → 4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors(2005)79 cited
- → Peripherin/rds Influences Membrane Vesicle Morphology(2000)75 cited
- → Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease(2017)69 cited
- → Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement(2003)63 cited