Spiros Liras
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Receptor Mechanisms and Signaling, Cyclopropane Reaction Mechanisms
Most-Cited Works
- → The Future of Peptide‐based Drugs(2012)1,918 cited
- → On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds(2011)376 cited
- → Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium(II) Carboxamide Catalysts(1995)215 cited
- → Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).(2009)201 cited
- → Comparative α‐Helicity of Cyclic Pentapeptides in Water(2014)174 cited
- → Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients(2014)167 cited
- → Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules(2017)153 cited
- → Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing(2018)153 cited
- → Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable(2014)139 cited
- → Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products(2015)134 cited