Joseph W. Lewcock
Denali Therapeutics (United States)(US)
Publications by Year
Research Areas
Neuroinflammation and Neurodegeneration Mechanisms, Alzheimer's disease research and treatments, Amyotrophic Lateral Sclerosis Research, Endoplasmic Reticulum Stress and Disease, RNA regulation and disease
Most-Cited Works
- → TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge(2020)713 cited
- → Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region(2020)349 cited
- → DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury(2013)338 cited
- → Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD(2019)266 cited
- → A feedback mechanism regulates monoallelic odorant receptor expression(2004)263 cited
- → Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia(2020)240 cited
- → The Ubiquitin Ligase Phr1 Regulates Axon Outgrowth through Modulation of Microtubule Dynamics(2007)234 cited
- → DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity(2011)227 cited
- → Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease(2020)216 cited
- → Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic(2021)215 cited