Salvatore Scaffidi
Universitat de Barcelona(ES)
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Chemical Synthesis and Analysis, Ubiquitin and proteasome pathways, Protein Structure and Dynamics, Peptidase Inhibition and Analysis
Most-Cited Works
- → Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities(2014)396 cited
- → Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space(2021)15 cited
- → Modulating Ligand Dissociation through Methyl Isomerism in Accessory Sites: Binding of Retinol to Cellular Carriers(2019)5 cited
- → Hydrophobic Waters in Bromodomains(2019)1 cited
- → Water Networks as Hydrophobic Recognition Motifs in Proteins(2025)1 cited
- → Drugging the Fbw7 E3 Ligase with a Fragment-Based Approach(2019)
- → Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators(2025)