Thomas O’Brien
Publications by Year
Research Areas
Sirtuins and Resveratrol in Medicine, PARP inhibition in cancer therapy, Autophagy in Disease and Therapy, Cancer, Hypoxia, and Metabolism, Cancer-related Molecular Pathways
Most-Cited Works
- → Fragment-Based Drug Discovery(2004)631 cited
- → Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors(2015)411 cited
- → Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death(2013)381 cited
- → Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation(1994)327 cited
- → Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition(2016)257 cited
- → Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells(2011)253 cited
- → Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer(2015)250 cited
- → Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism(2018)246 cited
- → Discovery of an allosteric site in the caspases(2004)241 cited
- → In situ assembly of enzyme inhibitors using extended tethering(2003)197 cited