Kenneth G. Kraus
Pfizer (United States)(US)
Publications by Year
Research Areas
Phosphodiesterase function and regulation, Mast cells and histamine, Cholinesterase and Neurodegenerative Diseases, Synthesis and Characterization of Heterocyclic Compounds, Chemical Synthesis and Analysis
Most-Cited Works
- → Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret(1996)143 cited
- → Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535(2011)75 cited
- → Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site(1995)45 cited
- → Pulmonary Eosinophilia in a Murine Model of Allergic Inflammation Is Attenuated by Small Molecule α4β1 Antagonists(2002)39 cited
- → SAR of a Series of 5,6-Dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines as Potent Inhibitors of Human Eosinophil Phosphodiesterase(2006)37 cited
- → 3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization(2009)32 cited
- → 1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis(2011)31 cited
- → 7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase(1998)29 cited
- → Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors(1989)19 cited
- → Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent α4β1 integrin antagonists(2001)13 cited