Katherine L. Lee
Pfizer (United States)(US)
Publications by Year
Research Areas
Protein Kinase Regulation and GTPase Signaling, NF-κB Signaling Pathways, Inflammatory mediators and NSAID effects, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography
Most-Cited Works
- → Discovery of Clinical Candidate 1-{[(2 S ,3 S ,4 S )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design(2017)139 cited
- → Indole Cytosolic Phospholipase A2α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib(2008)88 cited
- → The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists(2017)80 cited
- → Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α(2007)79 cited
- → Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses(2008)55 cited
- → Novel entry to the Ergot alkaloids via ring closing metathesis(2001)35 cited
- → Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy(2007)28 cited
- → Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice(2019)21 cited
- → Synthesis and Properties of 9-Alkyl- and 9-Arylcyclopenta[a]phenalenes(2000)20 cited
- → Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors(2009)18 cited