David B. Duignan
AbbVie (United States)(US)
Publications by Year
Research Areas
Drug Transport and Resistance Mechanisms, Pharmacogenetics and Drug Metabolism, Metabolomics and Mass Spectrometry Studies, Receptor Mechanisms and Signaling, Neuroscience and Neuropharmacology Research
Most-Cited Works
- → Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport(2006)212 cited
- → Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites(2010)148 cited
- → Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships(2009)126 cited
- → pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1(2011)118 cited
- → Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus(2011)115 cited
- → Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization(2020)105 cited
- → Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective(2017)85 cited
- → Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl(1987)85 cited
- → High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models(2008)84 cited
- → Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes(2009)81 cited