Brian Dymock
Publications by Year
Research Areas
Heat shock proteins research, Endoplasmic Reticulum Stress and Disease, Enzyme Structure and Function, Computational Drug Discovery Methods, Myeloproliferative Neoplasms: Diagnosis and Treatment
Most-Cited Works
- → NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis(2008)476 cited
- → 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer(2007)442 cited
- → Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms(2004)266 cited
- → Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design(2005)231 cited
- → SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies(2011)195 cited
- → Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma(2011)195 cited
- → Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone(2009)173 cited
- → Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues(2007)142 cited
- → Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets(2004)130 cited
- → TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties(2011)128 cited