John F. Harms
Messiah University(US)
Publications by Year
Research Areas
Phosphodiesterase function and regulation, Receptor Mechanisms and Signaling, Cholinesterase and Neurodegenerative Diseases, Neuroscience and Neuropharmacology Research, Pancreatic and Hepatic Oncology Research
Most-Cited Works
- → Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia(2008)284 cited
- → Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis(2006)274 cited
- → Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).(2009)201 cited
- → Kinetics of Metastatic Breast Cancer Cell Trafficking in Bone(2006)121 cited
- → Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models(2016)120 cited
- → Endogenous Osteonectin/SPARC/BM-40 Expression Inhibits MDA-MB-231 Breast Cancer Cell Metastasis(2005)114 cited
- → KISS1 metastasis suppression and emergent pathways(2003)114 cited
- → A small molecule antagonist of the α v β3 integrin suppresses MDA-MB-435 skeletal metastasis(2004)111 cited
- → Analysis of mechanisms underlying BRMS1 suppression of metastasis(2000)103 cited
- → Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington’s Disease(2010)95 cited