James M. Gavin
Education Development Center(US)
Publications by Year
Research Areas
Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Cancer-related Molecular Pathways, Autophagy in Disease and Therapy, Cancer, Hypoxia, and Metabolism
Most-Cited Works
- → An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer(2009)1,965 cited
- → Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase(2002)1,413 cited
- → Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ(2010)459 cited
- → A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment(2018)441 cited
- → Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors(2002)187 cited
- → A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models(2021)131 cited
- → Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924(2012)108 cited
- → Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues(2011)92 cited
- → Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway(2014)49 cited
- → Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6(2012)40 cited