Valerie Grum‐Tokars

Publications by Year

Research Areas

Computational Drug Discovery Methods, SARS-CoV-2 and COVID-19 Research, RNA and protein synthesis mechanisms, Melanoma and MAPK Pathways, RNA Research and Splicing

Most-Cited Works

• → Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery(2007)214 cited
• → Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease(2012)206 cited
• → Mutations in Capillary Morphogenesis Gene-2 Result in the Allelic Disorders Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis(2003)195 cited
• → Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance(2006)155 cited
• → Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors(2008)136 cited
• → Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding(2013)131 cited
• → Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors(2007)108 cited
• → Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models(2015)97 cited
• → Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer,(2005)86 cited
• → Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction(2013)77 cited