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Brigitte A. van Oirschot | doi.page

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Brigitte A. van Oirschot

Utrecht University(NL)University Medical Center Utrecht(NL)University Medical Center Utrecht(NL)

Publications by Year

Research Areas

Erythrocyte Function and Pathophysiology, Hemoglobinopathies and Related Disorders, Blood groups and transfusion, Iron Metabolism and Disorders, Blood properties and coagulation

Most-Cited Works

Tyrosine kinase activity in breast cancer, benign breast disease, and normal breast tissue.(1989)
→ The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis(2018)102 cited
→ Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway(2014)78 cited
→ AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes(2020)75 cited
→ Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients(2019)69 cited
→ Cyclin D3 Regulates Proliferation and Apoptosis of Leukemic T Cell Lines(1999)47 cited

→ In-vitro and in-silico evidence for oxidative stress as drivers for RDW(2023)

44 cited

→ Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy(2021)43 cited

→ Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in sickle cell disease: A phase 2, open‐label study(2022)41 cited

→ Fifteen novel mutations inPKLRassociated with pyruvate kinase (PK) deficiency: Structural implications of amino acid substitutions in PK(2008)36 cited