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J.K. Muckelbauer | doi.page

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J.K. Muckelbauer

Bristol-Myers Squibb (Germany)(DE)Bristol-Myers Squibb (United States)(US)Bristol-Myers Squibb (Sweden)(SE)

Publications by Year

Research Areas

Chronic Lymphocytic Leukemia Research, PI3K/AKT/mTOR signaling in cancer, Protein Kinase Regulation and GTPase Signaling, Computational Drug Discovery Methods, Synthesis and biological activity

Most-Cited Works

→ The structure of coxsackievirus B3 at 3.5 å resolution(1995)280 cited
→ Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers(2016)144 cited
→ The Structure of Coxsackievirus B3(1997)126 cited
→ Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain(2015)115 cited
→ Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)(2019)87 cited

→ Quinazolines as cyclin dependent kinase inhibitors(2001)

85 cited

→ Structure determination of coxsackievirus B3 to 3.5 Å resolution(1995)67 cited

→ Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)(2016)51 cited

→ Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis(2012)49 cited

→ Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors(2019)49 cited